Trametinib Alters Contractility of Paediatric Noonan Syndrome-Associated Hypertrophic Myocardial Tissue Slices
Ex vivo analysis of cultivated and electrically stimulated RV myocardial tissue slices of a patient with RAS-CM showed decreased contractility and improved sarcoplasmic reticulum function after addition of trametinib and in part after addition of rapamycin, but not after addition of dasatinib.
Authors
- Cordula M. Wolf (ORCID: https://orcid.org/0000-0003-4701-5843)
- Sarala Raj Murthi
- Andreas Dendorfer (ORCID: https://orcid.org/0000-0002-7806-312X)
- Julie Cleuziou (ORCID: https://orcid.org/0000-0002-1971-4375)
- Payel Sen (ORCID: https://orcid.org/0000-0002-1613-7760)
- Christian Meierhofer (ORCID: https://orcid.org/0000-0002-1367-3410)
- Maria von Stumm (ORCID: https://orcid.org/0000-0001-9578-0430)
- Daphne Merkus (ORCID: https://orcid.org/0000-0002-4852-831X)
- Jules Hamers (ORCID: https://orcid.org/0000-0002-9715-2005)
- Francesca Baessato (ORCID: https://orcid.org/0000-0002-2093-3671)
- Peter Ewert
- Laura Papanakli
Institutions
- Erasmus MC (NL)
- LMU Klinikum (DE)
- Ospedale di Bolzano (IT)
- German Centre for Cardiovascular Research (DE)
- Centre of Experimental Medicine of the Slovak Academy of Sciences (SK)
- Deutsches Herzzentrum München (DE)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1002/ehf2.15173
- Citations
- 4
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung