Altered mitochondrial mass and low mitochondrial membrane potential of immune cells in patients with HBV infection and correlation with liver inflammation
In this study, we conducted a systematic analysis of the percentage of lymphocyte MMP<sup>low</sup> and MM in various stages of HBV infection. Our findings revealed a correlation between MMP<sup>low</sup> and MM and early liver inflammation, as well as the progression of the infection. This study marked the first demonstration of the clinical diagnostic value of MMP<sup>low</sup> and MM in HBV infection. Furthermore, this was the first study to discuss the mitochondria of lymphocytes and liver inflammation in HBV infection. It enhanced the understanding of the role of T cells in liver inflammation, and elucidated potential markers for the early detection of liver injury and clinical cirrhosis.
Authors
- Qingzhen Han (ORCID: https://orcid.org/0000-0001-7373-891X)
- Longji Cheng
- Huafeng Song
- Rui Qiang
- Ping Xu (ORCID: https://orcid.org/0000-0002-1032-459X)
- Junchi Xu (ORCID: https://orcid.org/0000-0002-1447-7593)
- Fei Gao (ORCID: https://orcid.org/0000-0001-6179-6426)
- Liling Ma
- Li Zhu (ORCID: https://orcid.org/0000-0003-1583-2670)
Institutions
- Soochow University (CN)
- Suzhou Municipal Hospital (CN)
- The Fifth People’s Hospital of Suzhou (CN)
- The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-22
- DOI
- https://doi.org/10.3389/fimmu.2024.1477646
- Citations
- 10
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.87