Increased nuclear import characterizes aberrant nucleocytoplasmic transport in neurons from patients with spinocerebellar ataxia type 7
Our results reveal evidence for altered N/C transport in SCA7. The reduction in POM121 expression suggests a potential mechanism underlying these transport abnormalities. Importantly, our data suggests the N/C transport defect in SCA7 is distinctly different from other related neurodegenerative disorders.
Authors
- Marvin E. Adams
- Julien Philippe (ORCID: https://orcid.org/0000-0003-1906-7259)
- Albert R. La Spada (ORCID: https://orcid.org/0000-0001-6151-2964)
- Joshua G. Macopson-Jones
Institutions
- Duke University (US)
- University of California, Irvine (US)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2024-11-22
- DOI
- https://doi.org/10.3389/fnmol.2024.1478110
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health