Bioinformatics insights into the role of GFPT1 in breast invasive carcinoma: implications for tumor prognosis, immune modulation, and therapeutic applications
These findings indicate that GFPT1 is a novel prognostic biomarker and a predictive indicator of chemotherapy response in invasive breast carcinoma. GFPT1 influences mRNA translation, cell cycle regulation, and M2 macrophage infiltration, thereby promoting cancer cell proliferation and metastasis.
Authors
- Chengjie Yu (ORCID: https://orcid.org/0000-0001-9303-1436)
- T. Fei
- Muzi Ouyang
- Dongwei Jia
- Yingyi Zhang (ORCID: https://orcid.org/0000-0003-1020-7964)
- Yang Xiang (ORCID: https://orcid.org/0000-0002-9112-1021)
- Fangfang Duan
- Xiaolian Deng
- J. K. Liang (ORCID: https://orcid.org/0009-0002-6290-5748)
Institutions
- Sun Yat-sen University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2024-11-22
- DOI
- https://doi.org/10.3389/fgene.2024.1482929
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Fundamental Research Funds for the Central Universities