Clinical characteristics and biomarkers of severe immune checkpoint inhibitor-related pneumonitis triggered by immunotherapy followed by radiation: a case report
Our data highlight the imaging manifestations associated with ICI-related pulmonary toxicity and describe the dynamics of the corresponding circulating markers. Although our results reveal that dynamic monitoring of PLR and PMR as well as the levels of CD4<sup>+</sup>T and CD8<sup>+</sup>T cells may predict the risk of ICI-P, further investigations are needed to elucidate the underlying molecular and biological mechanisms for better management of ICI-P.
Authors
- Xiaohong Wu (ORCID: https://orcid.org/0000-0002-7489-6116)
- Hongxia Xu (ORCID: https://orcid.org/0000-0001-5215-734X)
- Jiang Liu (ORCID: https://orcid.org/0000-0001-9845-2619)
- Tian Tian (ORCID: https://orcid.org/0000-0002-9692-750X)
- Yan Zhu
- Jianhe Yu
- Qun Ren
Institutions
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-22
- DOI
- https://doi.org/10.3389/fimmu.2024.1454114
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.13