The Novel MoS <sub>2</sub>/MnO <sub>2</sub>–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic Therapy
Cellular photothermal and chemical kinetic therapy has recently been acknowledged as an effective cancer treatment method. Photothermal therapy (PTT) works by transforming light energy into heat through the photothermal effects triggered by near-infrared (NIR) laser exposure. The employment of nanomaterials as carriers for PTT agents or as PTT agents themselves offers improved therapeutic outcomes with fewer side effects through enhanced photothermal conversion efficiency, accumulation of the PTT agents in the tumor tissue. In this work, we synthesized new MoS<sub>2</sub>/MnO<sub>2</sub> nanomaterials modified with bovine serum protein to enhance the effectiveness of the Fenton-like reaction between MoS<sub>2</sub> and MnO<sub>2</sub> to produce •OH through photothermolysis excitation using a near-infrared (NIR) 808 nm laser. <i>In vitro</i> measurements further confirmed the exceptional ability of MoS<sub>2</sub>/MnO<sub>2</sub>–modified bovine hemoglobin (BSA) to destroy cancer cells. We believe that photothermal therapy can offer new insights into cancer therapy and greatly enhance the efficacy of chemotherapeutic tumor treatments.
Authors
- Tingting Xiang
- Kai Yang (ORCID: https://orcid.org/0000-0002-6670-1024)
- Yingying Yang (ORCID: https://orcid.org/0000-0001-9431-9925)
- Lingle Zhang
- Xiaoqing Qian
- Jinrong SiTu
- Hongzhang Yan
Institutions
- Tongji University (CN)
- Guangxi Medical University (CN)
- Guilin Medical University (CN)
- National Engineering Research Center for Nanotechnology (CN)
- Shanghai Sixth People's Hospital (CN)
- Shanghai Ocean University (CN)
Publication Details
- Journal
- Nano Biomedicine and Engineering
- Published
- 2024-11-22
- DOI
- https://doi.org/10.26599/nbe.2024.9290105
- Citations
- 6
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 1.11