Effects of Fractionated Proton Irradiation in Combination with 1-β-D-Arabinofuranosylcytosine on B16 Murine Melanoma In Vivo
This study is a search for means of sensitization of malignant tumors to proton radiation among DNA damage repair inhibitors. It has been found that in the presence of 1-β-D-arabinofuranosylcytosine (AraC), five weekly proton irradiations at a total focal dose of 50 Gy lead to a more pronounced inhibition of B16 murine melanoma growth than the same irradiation without AraC (p < 0.05 ). This effect, associated with a decrease in the proliferative activity of cells in the general population and a decrease in the number of cancer stem cells specifically in the AraC+Protons group, is promising for further improvement of proton radiotherapy.
Authors
- В. О. Сабуров (ORCID: https://orcid.org/0000-0002-6907-2753)
- V. N. Chausov
- V. A. Mosina
- S. A. Ivanov
- S. N. Koryakin
- И. А. Замулаева (ORCID: https://orcid.org/0000-0002-6136-8445)
- Olga N. Matchuk (ORCID: https://orcid.org/0000-0002-8644-6657)
- A. V. Boreyko
- А. Д. Каприн (ORCID: https://orcid.org/0000-0001-8784-8415)
- Е. И. Селиванова
- Abramova Mr (ORCID: https://orcid.org/0000-0002-0572-4054)
- E. A. Krasavin
Institutions
- Peoples' Friendship University of Russia (RU)
- Russian New University (RU)
- Joint Institute for Nuclear Research (RU)
- Ministry of Health (ES)
- Ministry of Health of the Russian Federation (RU)
- Medical Radiological Research Center (RU)
- P.A. Hertzen Moscow Oncology Research Institute (RU)
Publication Details
- Journal
- Physics of Particles and Nuclei Letters
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1134/s1547477124701784
- Citations
- 1
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.23