Exploring the biosynthesis potential of permafrost microbiomes
We have shown that arctic permafrost microbiomes harbor a unique biosynthetic repertoire rich in hitherto undescribed NRPs. This diversity is driven by geographic separation across kilometer scales and by the bacterial taxonomic diversity between microbiomes confined in separate permafrost layers. Hence the permafrost biome represents a unique resource for studying secondary metabolism, and potentially for the discovery of novel drug leads.
Authors
- Bo Elberling (ORCID: https://orcid.org/0000-0002-6023-885X)
- Morten Dencker Schostag (ORCID: https://orcid.org/0000-0001-9221-1398)
- Yannick Buijs (ORCID: https://orcid.org/0000-0002-9310-4161)
- Aileen U. Geers (ORCID: https://orcid.org/0000-0002-9162-9423)
- Mikkel Bentzon‐Tilia (ORCID: https://orcid.org/0000-0002-7888-9845)
Institutions
- University of Copenhagen (DK)
- École Polytechnique Fédérale de Lausanne (CH)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Environmental Microbiome
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1186/s40793-024-00644-8
- Citations
- 1
- Primary Topic
- Microbial Community Ecology and Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.46
Funders
- National Research Foundation
- Danmarks Grundforskningsfond
- Novo Nordisk
- Novo Nordisk Fonden
- Danmarks Frie Forskningsfond