Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation
Elocalcitol prevents development of senescence in microglia via modulation of miR-146a expression, while miR-146a provides protection against HFD-induced cellular senescence in the hypothalamus most probably via inhibition of TGF/Smad4 pathway. These findings highlight Elo and miR-146a as promising therapeutic candidates for ameliorating obesity-related neuroinflammation and senescence.
Authors
- Monika Jürgenson (ORCID: https://orcid.org/0000-0001-8060-5998)
- Alexander Zharkovsky (ORCID: https://orcid.org/0000-0003-1388-491X)
- Kalev Kask
- Keerthana Chithanathan (ORCID: https://orcid.org/0000-0002-6940-6231)
- Ana Rebane (ORCID: https://orcid.org/0000-0001-6051-1361)
- Kristīne Ducena
- Anu Remm (ORCID: https://orcid.org/0000-0002-5538-6866)
- Tian Li (ORCID: https://orcid.org/0000-0002-3196-2750)
Institutions
- Edison Pharmaceuticals (United States) (US)
- University of Tartu (EE)
Publication Details
- Journal
- Immunity & Ageing
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1186/s12979-024-00485-6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00