Phylum Firmicutes in the Faecal Microbiota Demonstrates a Direct Association with Arterial Hypertension in Individuals of the Kazakh Population Without Insulin Resistance

The gut microbiota plays a fundamental role in the host's energy metabolism and the development of metabolic diseases such as arterial hypertension, insulin resistance, and atherosclerosis. Our study aimed to investigate the potential role of the gut microbiota in arterial hypertension among individuals of the Kazakh population without insulin resistance. 16S rRNA gene sequencing of faecal samples from 197 Kazakh subjects was performed. Preliminary binary comparisons of the faecal microbiota composition depending on the presence of arterial hypertension and insulin resistance revealed statistically significant differences in the abundance of the <i>phylum Firmicutes</i>. Logistic regression analysis showed that only the <i>phylum Firmicutes</i> influenced hypertension risk in individuals without insulin resistance after adjusting for age, sex, BMI, fasting glucose, triglycerides, and triglyceride-glucose index. The higher the abundance of the <i>phylum Firmicutes</i> in faeces, the greater the risk of arterial hypertension (OR = 1.064 [95% CI 1.005-1.125]). Correlation analysis revealed a negative association between the abundance of the <i>phylum Firmicutes</i> and the triglyceride-glucose index, primarily driven by triglyceride levels. These findings suggest the potential role of the gut microbiota, especially the <i>phylum Firmicutes</i>, in the development of hypertension in individuals without insulin resistance.