Exploring Orodispersible Films Containing the Proteolysis Targeting Chimera ARV-110 in Hot Melt Extrusion and Solvent Casting Using Polyvinyl Alcohol
The findings from the experiments outlined herein establish a solid foundation for the successful production of orodispersible films for the delivery of PROTACs.
Authors
- Lena Mareczek
- Nadine Gottschalk (ORCID: https://orcid.org/0000-0001-8157-7685)
- Liang Bian (ORCID: https://orcid.org/0000-0002-2769-7018)
- Laura Halstenberg
- Jian Sheng Lu
- Lena Karin Mueller
- Valentina Meloni
Institutions
- Merck KGaA, Darmstadt (Germany) (DE)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2024-11-22
- DOI
- https://doi.org/10.3390/pharmaceutics16121499
- Citations
- 3
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.70