Dietary contributions in the genetic variation of liver fibrosis: a genome-wide association study of fibrosis-4 index in the liver fibrosis development
The studies not only revealed the protective role of rs9399136 (HBS1L) and the risk effect of rs9274407 (HLA-DQB1) toward liver fibrosis in a Taiwanese population, but also demonstrated that individual consumption patterns, such as tea uptake, have a minor impact on liver fibrosis prevention. The pathway analysis from GWAS variants further indicated the importance of immune responses in the pathogenesis of liver fibrosis.
Authors
- Wan‐Hsuan Chou (ORCID: https://orcid.org/0000-0002-7693-5959)
- Chun-Yu Wei
- Min‐Rou Lin (ORCID: https://orcid.org/0000-0003-0247-1984)
- Wei‐Chiao Chang (ORCID: https://orcid.org/0000-0002-8573-5924)
- Poppy Diah Palupi
- Yu-Jui Yvonne Wan
Institutions
- University of California Davis Medical Center (US)
- Taipei Medical University (TW)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1186/s13578-024-01321-6
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Taipei Medical University
- National Science and Technology Council