Evaluation of the relationship between gastroesophageal reflux disease and glycogenic acanthosis

Aims: This study aims to evaluate the possible etiologic factors, espacially GERD, in the presence of glycogenic acanthosis (GA). Methods: A total of 387 patients who underwent upper gastrointestinal endoscopy between November 2023 and April 2024 were enrolled for the study. Participants were divided into two groups on the basis of the presence of GA. Groups were compared in terms of factors such as age, smoking, GERD, hiatal hernia, and helicobacter pylori. Results: Group comparasion revealed no significant difference except the presence of hiatus hernia, and GERD which was observed higher in the GA (+) group (p <0.001, for both parameters). In terms of the identification of the predictors of GA positivity, univariate and multiple variate analysis were performed. Only GERD (OR: 7.628, 95% CI: 3.202-18.169, p < 0.001) and hiatus hernia (OR: 3.449, 95% CI: 1.387-8.579, p = 0.008) were demonstrated as independent predictors of GA positivity in the multiple variate analysis. Conclusion: In this study, we demonstrated that GA may be associated with GERD and hiatal hernia.