Non-crosslinked hyaluronic acid mesotherapy and hydro-exfoliation plus infrared technology: a combination protocol to improve skin quality

Smooth, healthy-looking skin is a desired aesthetic goal for all age groups. This study evaluated a new protocol combining non-crosslinked hyaluronic acid (HA) with hydro-exfoliation and infrared technology for improving skin quality parameters. This retrospective, single-center medical data analysis included subjects aged 18 to 65 in good general health, with signs of skin atrophy or aging in the face or neck area. On Day 0, subjects underwent mesotherapy with injections of non-crosslinked HA (18 mg/mL) with 0.01% calcium hydroxyapatite, glycine, and l-proline to a depth of 0.5 to 4 mm. On Day 7, this was followed by treatment with a combined hydro-exfoliation and infrared device. Visual improvements in skin quality parameters (wrinkles, pores, brown spots, texture, and oiliness) were assessed by a blinded evaluator using photographs taken prior to treatment and 2 weeks after the final treatment with a facial analysis imaging system. The medical data analysis included 22 subjects with a mean age of 45 years (range 28 to 65 years). Comparison of post-treatment with baseline images showed improvements in wrinkles of 13%-23%, pores of 16%-30%, skin texture of 15%-28%, and oiliness of 10%-33%; brown spots improved by 0.1%-0.7%. All treatments were well tolerated. In conclusion, the combination of non-crosslinked HA mesotherapy, hydro-exfoliation, and infrared technology led to visible improvements in several skin quality parameters across a wide age range. While the study demonstrated cosmetic benefits, further research is needed to assess the safety profile of these treatments in more detail, as the current methodology was not designed to specifically evaluate device safety.