Whole genome sequencing-based characterization and determination of quinolone resistance among methicillin-resistant and methicillin-susceptible S. Aureus isolates from patients attending regional referral hospitals in Tanzania
There is a high genetic diversity among the S. aureus isolates existing in Tanzania regional hospitals, with a concerning burden of quinolone resistance among MRSA isolates. The diversity in resistance genes among MRSA lineages emphasizes the necessity for the development of sustainable antimicrobial stewardship and surveillance to support evidence-based guidelines for managing and controlling MRSA infections in both community and hospital settings.
Authors
- Davis Kuchaka (ORCID: https://orcid.org/0000-0002-0991-703X)
- Boaz Wadugu (ORCID: https://orcid.org/0009-0000-8632-859X)
- Marco van Zwetselaar (ORCID: https://orcid.org/0000-0002-5953-0060)
- Happiness Kumburu (ORCID: https://orcid.org/0000-0002-9179-6141)
- Tolbert Sonda (ORCID: https://orcid.org/0000-0001-5279-5421)
- Mariana J. Shayo (ORCID: https://orcid.org/0000-0002-7756-8142)
- Masoud A. Juma
- Blandina Theophil Mmbaga (ORCID: https://orcid.org/0000-0002-5550-1916)
- Patrick Kimu
- Livin E. Kanje
- Melkiory Beti (ORCID: https://orcid.org/0009-0001-5364-661X)
Institutions
- Muhimbili University of Health and Allied Sciences (TZ)
- Kilimanjaro Christian Medical Centre (TZ)
- State University of Zanzibar (TZ)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1186/s12864-024-11045-z
- Citations
- 5
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- Danida Fellowship Centre
- Danish International Development Agency