Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema
This study indicates that PICT1 dysfunction can negatively affect genome stability and mitochondrial activity in ATII cells, contributing to emphysema development. Targeting PICT1 can lead to novel therapeutic approaches for this disease.
Authors
- Gerard J. Criner (ORCID: https://orcid.org/0000-0003-1267-3483)
- John W. Elrod (ORCID: https://orcid.org/0000-0003-3925-2224)
- Sudhir Bolla
- Hannah Leah Tadeja Simborio (ORCID: https://orcid.org/0000-0003-0128-1740)
- Hassan Hayek (ORCID: https://orcid.org/0000-0001-6250-0535)
- Nathaniel Marchetti (ORCID: https://orcid.org/0000-0003-3229-8879)
- Beata Kośmider (ORCID: https://orcid.org/0000-0001-7421-5424)
- Karim Bahmed (ORCID: https://orcid.org/0000-0001-9854-5452)
Institutions
- Temple University (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1186/s12964-024-01896-0
- Citations
- 3
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Temple University
- National Institutes of Health