Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities
Our study thus illustrates how tumour suppressor gene LOF alterations can be exploited to reveal potentially targetable cancer cell vulnerabilities.
Authors
- Richard A. Moore
- Daniel J. Renouf (ORCID: https://orcid.org/0000-0002-7597-6089)
- Erin Pleasance (ORCID: https://orcid.org/0000-0002-5104-042X)
- Ryan D. Huff (ORCID: https://orcid.org/0000-0002-6038-8217)
- Alessia Gagliardi (ORCID: https://orcid.org/0000-0002-6024-503X)
- Eleanor Lewis
- Jessica Nelson (ORCID: https://orcid.org/0000-0002-6062-6051)
- Andrew J. Mungall (ORCID: https://orcid.org/0000-0002-0905-2742)
- Kathleen Wee
- Yuka Takemon (ORCID: https://orcid.org/0000-0002-3538-4409)
- Veronika Csizmók
- Diane L. Trinh (ORCID: https://orcid.org/0000-0001-9846-9840)
- Steven A. Jones (ORCID: https://orcid.org/0000-0002-0897-5502)
- Marco A. Marra (ORCID: https://orcid.org/0000-0001-7146-7175)
- Christopher S. Hughes (ORCID: https://orcid.org/0000-0002-6980-4459)
- Janessa Laskin (ORCID: https://orcid.org/0000-0002-0161-9329)
- Howard J. Lim (ORCID: https://orcid.org/0000-0002-5814-714X)
- Karen Mungall (ORCID: https://orcid.org/0000-0002-9092-4391)
- Eric Chuah
Institutions
- Dalhousie University (CA)
- Vancouver Coastal Health (CA)
- University of British Columbia (CA)
- Canada's Michael Smith Genome Sciences Centre (CA)
- Vancouver Coastal Health Research Institute (CA)
- Pancreas Centre (Canada) (CA)
Publication Details
- Journal
- Genome Medicine
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1186/s13073-024-01401-9
- Citations
- 3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Canada's Michael Smith Genome Sciences Centre
- Genome British Columbia
- BC Cancer Foundation