<i>APOE</i> ε4–associated heterogeneity of neuroimaging biomarkers across the Alzheimer's disease continuum
An extensive study was performed on the apolipoprotein E (APOE) ε4-associated heterogeneity in neuroimaging biomarkers from the Alzheimer's Disease Neuroimaging Initiative. Robust APOE ε4-associated increases in amyloid beta (Aβ) deposition throughout the brain, in every diagnostic group, were observed. APOE ε4-associated increases in tau pathology, decreases in glucose uptake, and increases in brain atrophy, which expand in regional scope and magnitude with disease progression, were observed. Significant sex- and age-related differences in APOE ε4-associated neuroimaging biomarker heterogeneity, with overall increases in pathological presentation in female APOE ε4 carriers, were observed. Regional differences in Aβ deposition, tau accumulation, glucose uptake, ventricle size, and white matter hyperintensities were observed in cognitively normal participants who converted to mild cognitive impairment/Alzheimer's disease, which may hold potential predictive value.
Authors
- Jason Mares
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- Anurag Sharma (ORCID: https://orcid.org/0000-0001-5345-8830)
- Laura Beth McIntire (ORCID: https://orcid.org/0000-0002-9565-8889)
- Tal Nuriel (ORCID: https://orcid.org/0000-0002-5252-8048)
- Sheina Emrani
- Jia Guo (ORCID: https://orcid.org/0000-0001-8036-5349)
- Gautam Kumar (ORCID: https://orcid.org/0000-0001-6207-9568)
Institutions
- University of Maryland, Baltimore (US)
- Cornell University (US)
- Weill Cornell Medicine (US)
- Columbia University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1002/alz.14392
- Citations
- 6
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- Foundation for the National Institutes of Health
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- Meso Scale Diagnostics
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research
- National Institute on Aging