Motor Activity of the Hollow Organs of the Digestive System in Pseudomembranous Colitis

Materials and Methods: 86 PC patients were examined.Patients complain of liquid stools more than 3-5 times a day, body temperature up to 39 C, flatulence, rarely nausea, vomiting, spastic abdominal pain.Anamnestically, patients before the development of clinical symptoms may have undergone surgical treatment, the use of antibacterial drugs.The motor function of stomach, small intestine and right and left colon sections, as well as biliary tract was recorded electromyographically using CONAN-M electromyograph with evaluation of amplitude-frequency characteristics of slow waves and spasms, power of phasic and tonic contractions and propulsive activity.Statistical processing was performed by Mann-Whitney test at p<0.05.Results: Increased excitability of longitudinal, circular and partially oblique gastric muscles and the presence of both antegrade and retrograde contractions of gastric smooth muscles were revealed.The unfavourable influence of Clostridii defficile toxins on excitability of longitudinal and circular muscles and neuromuscular apparatus of the small intestine was revealed.Hypermotor dyskinesia of the left colon with a spastic component due to increased excitability of the longitudinal and circular muscle layers caused by hyperexcitability of the intramural nervous apparatus of the small intestine was revealed in PC. Conclusions:1. Hypermotor dyskinesia of the left colon with increased excitability of the intermuscular nerve plexus and predominance of the activity of the longitudinal muscle layer, which ensures the development of diarrhoea, is revealed in PC. 2. Hypomotor dyskinesia of choledochus and gallbladder due to proportional increase of excitability of longitudinal and circular muscular layers was revealed in PC.Hypomotor dyskinesia can be caused by increased excitability under the influence of toxins of clostridial infection of sympathetic efferent fibres.3 Electromyography can be used for objective assessment of the state of the neuromuscular apparatus of the colon.