Pharmacological inhibition of the NLRP3 inflammasome attenuates kidney apoptosis, fibrosis, and injury in Dahl salt-sensitive rats
The findings suggest that pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure in SS rats and alleviates related kidney injury by suppressing inflammation, apoptosis, fibrosis, and sodium retention.
Authors
- Yuhang Wu (ORCID: https://orcid.org/0000-0001-9860-1434)
- Peng Qu (ORCID: https://orcid.org/0009-0002-3795-3975)
- Jiayu Ren
- Imran Perwaiz
- Ying Wang (ORCID: https://orcid.org/0000-0002-1407-2668)
- Yue Wang (ORCID: https://orcid.org/0009-0000-4441-430X)
- Hao Su (ORCID: https://orcid.org/0000-0003-0519-6471)
- Jing Li (ORCID: https://orcid.org/0009-0000-6253-6423)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Clinical and Experimental Nephrology
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1007/s10157-024-02567-7
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Doctoral Start-up Foundation of Liaoning Province
- Dalian Medical University
- Dalian Institute of Chemical Physics