Spirolones A–E, five spiroketals from a productive saline soil derived Penicillium raistrickii

The results suggested that compound <b>4</b> displayed some activity against P. aeruginosa and E. coli with MIC values of 35.00 μg/mL and 55.00 μg/mL, with MIC values of the positive control of streptomycin at 12.50 μg/mL and 8.00 μg/mL, respectively. Compound <b>5</b> exhibited inhibitory effect against HepG2 cell line with IC50 value of 3.40 μM, and 8.14 μM against Hep3B cell line with doxorubincin as positive control. Compounds <b>4</b> and <b>5</b> may be capable of contribution for the development of new antibiotics or antitumor agents.