Neuroprotective Potential of Nitroglycerin in Ischemic Stroke: Insights into Neural Glucose Metabolism and Endoplasmic Reticulum Stress Inhibition
GTN induced neuroprotection in transient MCAO by improving glucose metabolism and potentially controlling endoplasmic reticulum stress through the NO-cGMP-PKG signaling cascade to inhibit AMPK phosphorylation.
Authors
- Enoch Kim (ORCID: https://orcid.org/0009-0003-3248-3545)
- Yuchuan Ding (ORCID: https://orcid.org/0000-0001-5358-1660)
- Xiaokun Geng (ORCID: https://orcid.org/0000-0001-8918-8748)
- Hongrui Wang (ORCID: https://orcid.org/0000-0002-2916-8849)
- Shangqian Jiang
Institutions
- Wayne State University (US)
- Beijing Luhe Hospital Affiliated to Capital Medical University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1161/jaha.124.035382
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.24
Funders
- National Natural Science Foundation of China