Spatiotemporal neurodegeneration of the substantia nigra and its connecting cortex and subcortex in Parkinson's disease
Iron deposition in SN functional subregions and atrophy of cortical and subcortical structures connected with the SN showed spatiotemporal selectivity. These findings reveal the potential pathogenesis of clinical heterogeneity in PD.
Authors
- Jun Tian (ORCID: https://orcid.org/0000-0003-4950-3963)
- Baorong Zhang (ORCID: https://orcid.org/0000-0002-8099-7407)
- Xiaojie Duanmu
- Xiaojun Guan (ORCID: https://orcid.org/0000-0003-2313-4477)
- Sijia Tan
- Jingwen Chen (ORCID: https://orcid.org/0000-0001-6404-6858)
- Hui Hong (ORCID: https://orcid.org/0000-0002-8807-7859)
- Jianmei Qin
- Minming Zhang (ORCID: https://orcid.org/0000-0003-0145-7558)
- Tao Guo (ORCID: https://orcid.org/0000-0002-7340-3762)
- Shuyue Wang (ORCID: https://orcid.org/0000-0002-6099-4452)
- Xiaojun Xu (ORCID: https://orcid.org/0000-0002-0127-2812)
- Jingjing Wu (ORCID: https://orcid.org/0000-0002-6396-817X)
- Chenqing Wu
- Weijin Yuan
- Cheng Zhou (ORCID: https://orcid.org/0000-0001-8025-5967)
- Jiaqi Wen (ORCID: https://orcid.org/0000-0001-9723-4695)
- Yaping Yan (ORCID: https://orcid.org/0000-0002-9309-4848)
- Qianshi Zheng
- Xiting Peng (ORCID: https://orcid.org/0000-0002-7111-8458)
- Yuelin Fang
- Haoting Wu
- Bingting Zhu
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1111/ene.16546
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China