Plasmalogens Improve Lymphatic Clearance of Amyloid Beta from Mouse Brain and Cognitive Functions
Amyloid beta (Aβ) is a neuronal metabolic product that plays an important role in maintaining brain homeostasis. Normally, intensive brain Aβ formation is accompanied by its effective lymphatic removal. However, the excessive accumulation of brain Aβ is observed with age and during the development of Alzheimer's disease (AD) leading to cognitive impairment and memory deficits. There is emerging evidence that plasmalogens (Pls), as one of the key brain lipids, may be beneficial for AD and cognitive aging. Here, we studied the effects of Pls on cognitive functions and the lymphatic clearance of Aβ from the brain of AD mice and mice of different ages. The results showed that Pls effectively reduce brain Aβ levels and facilitate learning in aged but not old mice. In AD mice, Pls improve the lymphatic clearance of Aβ that is accompanied by an increase in general motor activity and an improvement of the emotional status and learning ability. Thus, these findings suggest that Pls could be a promising candidate for the alternative or concomitant therapy of AD and age-related brain diseases to enhance the lymphatic clearance of Aβ from the brain and cognitive functions.
Authors
- Alexander Shirokov (ORCID: https://orcid.org/0000-0003-4321-735X)
- Ivan V. Fedosov (ORCID: https://orcid.org/0000-0002-3619-245X)
- Oxana Semyachkina‐Glushkovskaya (ORCID: https://orcid.org/0000-0001-6753-7513)
- Sergey Popov (ORCID: https://orcid.org/0000-0002-4075-9092)
- Andrey Terskov
- Alexander Dubrovsky (ORCID: https://orcid.org/0000-0002-5897-9229)
- Maria O. Tsoy
- Elena L. Vodovozova (ORCID: https://orcid.org/0000-0003-0164-7423)
- Sergey P. Kasyanov (ORCID: https://orcid.org/0000-0002-5335-3999)
- Matvey Tuzhilkin
- Alexander Dmitrenko
- Arina Evsyukova
- Dmitry Myagkov (ORCID: https://orcid.org/0009-0002-7781-6721)
- Inna Blokhina (ORCID: https://orcid.org/0000-0003-1517-0857)
- Nikita Navolokin (ORCID: https://orcid.org/0000-0001-7876-9758)
- Maria Manzhaeva
- Valeria Krupnova
- Egor Ilyukov
- Dmitry Tuktarov
- Daria Zlatogosrkaya
- Inna Elezarova
- Ruslan Sultanov
- Viktoria Adushkina
- Anastasiia Semiachkina-Glushkovskaia
- Tymophey Inozemzev
- Kristina Kardashevskaya
Institutions
- Saratov State University (RU)
- Institute of Bioorganic Chemistry (RU)
- Institute of Biochemistry and Physiology of Plants and Microorganisms (RU)
- Saratov State Medical University (RU)
- A.V. Zhirmunsky National Scientific Center of Marine Biology Far Eastern Branch of the Russian Academy of Sciences (RU)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2024-11-22
- DOI
- https://doi.org/10.3390/ijms252312552
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- Russian Science Foundation