Optimization of HPMC Loaded Paroxetine HCl Controlled Release Matrix Tablet by Central Composite Design

The main aim of the present study was to improve the release profile of Paroxetine (PXT) using Novel Drug Delivery System (NDDS). Therefore, Controlled Release Matrix tablet of PXT was prepared to extend the release of the drug from 8 hours to 12 hours. In the present research work, controlled release matrix tablet of paroxetine (PXT) was prepared by wet granulation method using various polymer grades of Hydroxypropyl methylcellulose (HPMC) and Polyvinylpyrrolidone (PVP) like HPMC K100M, HPMC K4M, HPMC K100M LV, and PVP K-30. Central Composite Design was applied to optimize the amount of polymers in the tablet. Infrared Spectroscopic analysis was done to check the interaction between drug and polymers. Results showed that all pre-compression and post-compression parameters were as per standard limits and not deviated when compared with the marketed formulation. The release profile of the tablet formulated using optimized batch was also improved significantly. Specifically, PXT matrix tablet released approximately 29.382%, 41.29%, and 93.47% of the drug at the second, fourth, and twelfth hours, respectively. In conclusion, the dissolution profile of the optimized batch aligns closely with the established USP guidelines for PXT extended-release formulations.