Aβ status assessment in a hypothetical scenario prior to treatment with disease‐modifying therapies: Evidence from 10‐year real‐world experience at university memory clinics
We evaluated cerebrospinal fluid (CSF) and positron emission tomography (PET) amyloid beta (Aβ) biomarkers for Alzheimer's disease in real-world cohorts.A CSF Aβ 42/40 ratio between 5.5% and 7.1% defines patients at borderline levels.Patients at borderline levels strongly benefit from additional Aβ PET imaging.Two-cutoff CSF Aβ 42/40 and PET will allow effective treatment stratification.
Authors
- Robert Perneczky (ORCID: https://orcid.org/0000-0003-1981-7435)
- Tatjana Traub‐Weidinger (ORCID: https://orcid.org/0000-0003-1118-926X)
- Sigrid Klotz (ORCID: https://orcid.org/0000-0003-3096-2852)
- Günther Regelsberger (ORCID: https://orcid.org/0000-0002-3233-1491)
- Elisabeth Stögmann (ORCID: https://orcid.org/0000-0003-4688-8482)
- Boris‐Stephan Rauchmann (ORCID: https://orcid.org/0000-0003-4547-6240)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Katharina Büerger (ORCID: https://orcid.org/0000-0002-5898-9953)
- Johannes Gnörich (ORCID: https://orcid.org/0000-0003-1554-7765)
- Sara Silvaieh
- Tandis Parvizi (ORCID: https://orcid.org/0000-0001-6989-7539)
- Axel Rominger (ORCID: https://orcid.org/0000-0002-1954-736X)
- Carolin Kurz (ORCID: https://orcid.org/0000-0003-4299-6240)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Wolfgang G. Kunz (ORCID: https://orcid.org/0000-0002-5021-1952)
- Daniel Janowitz (ORCID: https://orcid.org/0009-0003-4090-547X)
- Alexander Drzezga (ORCID: https://orcid.org/0000-0001-6018-716X)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Raphael Wurm (ORCID: https://orcid.org/0000-0003-3027-7775)
- Dirk Mehrens (ORCID: https://orcid.org/0000-0001-5114-8935)
- Julia Kusche‐Palenga
- A. Kling
- Antonia Buchal
- Matthias Brendel
- Elizabet Nestorova
- Christof Elias Topfstedt
Institutions
- University of Bern (CH)
- Forschungszentrum Jülich (DE)
- University Hospital of Bern (CH)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Donauspital (AT)
- Munich Cluster for Systems Neurology (DE)
- University Hospital Cologne (DE)
- Imperial College London (GB)
- Medical University of Vienna (AT)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
- University of Sheffield (GB)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/dad2.70031
- Citations
- 6
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.31
Funders
- Alzheimer's Association
- Stiftung VERUM
- Alzheimer Forschung Initiative
- National Institute for Health and Care Research
- European Commission
- Deutsche Forschungsgemeinschaft
- Deutsches Zentrum für Neurodegenerative Erkrankungen