Plasma pTau217 ratio predicts continuous regional brain tau accumulation in amyloid‐positive early Alzheimer's disease
NCT03887455 (ClarityAD) HIGHLIGHTS: Developed a model using plasma pTau217R to predict tau levels across brain regions. pTau217R model outperformed models based on clinical, MRI, and other blood biomarkers. The model reliably predicted tau levels exceeding tau positivity and higher thresholds. Screening with pTau217R could reduce tau PET scans by 65% at 95% sensitivity. pTau217R model aids in disease staging and monitoring in early AD.
Authors
- T. Doherty (ORCID: https://orcid.org/0000-0002-4183-5595)
- Arnaud Charil (ORCID: https://orcid.org/0000-0002-3437-1710)
- Erica Andreozzi
- Shobha Dhadda (ORCID: https://orcid.org/0000-0002-7290-7168)
- Harald Hampel (ORCID: https://orcid.org/0000-0003-0894-8982)
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
- Viswanath Devanarayan (ORCID: https://orcid.org/0000-0003-2059-9252)
- Daniel A. Llano (ORCID: https://orcid.org/0000-0003-0933-1837)
- Larisa Reyderman
- Yuanqing Ye (ORCID: https://orcid.org/0000-0001-5708-8961)
- Kanta Horie (ORCID: https://orcid.org/0000-0001-7736-2614)
- Jin Zhou
- Michael C. Irizarry (ORCID: https://orcid.org/0000-0002-0246-2511)
- Lynn D. Kramer
- Leema Krishna Murali
Institutions
- University of Illinois Urbana-Champaign (US)
- Illinois College (US)
- Washington University in St. Louis (US)
- University of Illinois Chicago (US)
- Eisai (United Kingdom) (GB)
- Eisai (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1002/alz.14411
- Citations
- 12
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.92