Amelioration of Neuronal Deficits in Aged Rats Via <i>Ganoderma lucidum</i> Extract Alone and Combination with Alpha Lipoic Acid

Background Ageing is associated with progressive neuronal deficits, leading to cognitive decline and increased vulnerability to neurodegenerative diseases. Currently, there is no permanent treatment available which can cure ageing and associated neuronal deficits. Objectives The purpose of this investigation was to examine the neuroprotective effects of Ganoderma lucidum extract (GLE), both alone and in combination with alpha lipoic acid (ALA), on age-related neuronal deficits in old rats. Materials and Methods Eight groups of rats were used in this investigation. GLE and ALA were administered alone and in combination for 90 days orally. After 90 days, various physiological, behavioural, oxidative stress and histopathological parameters were assessed. Results Treatment with GLE and ALA significantly and dose-dependently modulates the neuronal deficits of aged rats. GLE 100 with ALA 50 showed synergistic effects on aged rats. Conclusion New recent data supports the benefits of GLE for cognitive deficits in aged rats.