The substituted derivative of <i>closo</i>-dodecaborate anion based on <i>para</i>-iodo-L-phenylalanine is a novel compound for BNCT with CT imaging capability
A substituted derivative of closo-dodecaborate anion [B12H11NH=C(CH3)NHCH2CH-4-I-C6H4(COOCH3)]– containing in its structure elements for vector delivery and diagnostics by beam imaging methods was obtained. The structure of the co-compound was established by multinuclear NMR spectroscopy and ESI-mass spectrometry. For aqueous solutions of the compound Na[B12H11NH=C(CH3)NHCH2CH-4-I-C6H4(COOCH3)], the X-ray density was measured and the distribution of the drug in the organs of laboratory animals was studied by computer tomography.
Authors
- Yu. А. Finogenova (ORCID: https://orcid.org/0000-0002-5144-1039)
- К. Yu. Zhizhin (ORCID: https://orcid.org/0000-0002-4475-124X)
- А. V. Nelyubin (ORCID: https://orcid.org/0000-0002-9990-4231)
- А. P. Zhdanov
- Е. Yu. Grigorieva (ORCID: https://orcid.org/0000-0001-7726-7991)
- Н. Т. Кузнецов (ORCID: https://orcid.org/0000-0002-2562-6427)
- V. А. Skribitsky (ORCID: https://orcid.org/0000-0003-2942-7895)
- А. А. Lipengolts (ORCID: https://orcid.org/0000-0002-5631-9016)
- М. N. Ryabchikova
Institutions
- National Research University Higher School of Economics (RU)
- Russian Academy of Sciences (RU)
- Institute of General and Inorganic Chemistry (BG)
- Ministry of Health of the Russian Federation (RU)
- National Research Nuclear University MEPhI (RU)
Publication Details
- Journal
- Журнал неорганической химии
- Published
- 2024-11-21
- DOI
- https://doi.org/10.31857/s0044457x24050088
- Primary Topic
- Boron Compounds in Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00