Developments and opportunities in regenerative medicine materials

In recent years, with the rapid progress of science and technology, remarkable progress has been made in the application and development of regenerative medical materials in the field of medicine. In particular, breakthroughs have been made in functional biomaterials, stem cell regenerative medicine, biological regenerative materials and organ bioprinting, which have become a research hotspot and have received extensive attention. The combination of functional biomaterials and stem cell regenerative medicine is a revolutionary advance. This stem cell-based treatment method, which exploits its self-renewal and multi-directional differentiation potential, has shown great potential in the treatment of aging-related diseases as well as some refractory diseases. In this process, engineered functional regenerative medicine materials play a crucial role. By finely regulating the microenvironment of stem cells, they can significantly affect the behavior of stem cells, including cell implantation, survival, migration, and finally differentiation, thereby effectively enhancing the implantation effect of stem cells and guiding tissue regeneration in the desired direction. The research and development of functional biomaterials enables us to design materials that are more compatible with human tissues and can promote cell growth and tissue repair. These materials can be used as scaffolds to provide cells with the necessary physical and chemical signals to promote tissue regeneration. Research on bioregenerative materials, including the development of natural and synthetic materials, provides new directions for tissue engineering. These materials can mimic the properties of natural extracellular matrix and promote cell adhesion, proliferation, and differentiation, thereby accelerating wound healing and tissue repair. Organ bioprinting uses 3D printing technology to combine biological materials and cells to produce biologically active tissue structures, which provides a new solution for personalized medicine and complex organ replacement. The unique properties of regenerative medicine materials make them widely used in drug delivery, diagnostic imaging, tissue engineering and other fields. In terms of drug delivery, the design of controlled release systems can improve drug efficacy and reduce side effects. In the field of diagnostic imaging, regenerative medicine materials can enhance the imaging signal and improve the accuracy of diagnosis. In tissue engineering, these materials can serve as scaffolds for cell growth and promote the formation of new tissues. Although regenerative medicine materials have shown great potential in the fields of treating degenerative diseases, aging-related diseases, and wound repair, they also face a series of challenges. These challenges include how to improve the biocompatibility of materials, how to ensure the long-term stability of materials <italic>in vivo</italic>, how to control the degradation rate of materials to match the regeneration rate of tissues, etc. This review discusses in detail the medical applications and related mechanisms of regenerative medicine materials from four aspects: Open surgery regeneration, minimally invasive surgery regeneration, non-invasive surgery regeneration, and smart wearable regeneration. Open surgical regeneration involves traditional surgical methods to promote tissue repair by implanting biomaterials. Minimally invasive surgical regeneration utilizes less invasive procedures to reduce patient pain and recovery time. Non-invasive surgical regenerative technologies, such as ultrasound and magnetic field-guided drug delivery, provide safer and more convenient treatment methods. Smart wearable regeneration combines wearable technology and biomaterials to provide real-time monitoring and treatment for patients. This review discusses the challenges, development prospects, and opportunities for clinical translation of regenerative medicine materials at this stage, in order to lay a foundation for researchers to explore more diverse medical applications of regenerative medicine materials, and provide inspiration for the final realization of clinical translation.