Distinct epigenetic and transcriptional profiles of Epstein-Barr virus-positive and negative primary CNS lymphomas

EBV+ and EBV- PCNSL harbor distinct transcriptional and epigenetic profiles, corroborating them as distinctive biological subtypes. Uncovered differences provide novel insights into their pathobiology, may guide molecular diagnostics and targeted therapies.

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Publication Details

Journal
Neuro-Oncology
Published
2024-11-22
DOI
https://doi.org/10.1093/neuonc/noae251
Citations
5
Primary Topic
CNS Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
1.85

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article

Distinct epigenetic and transcriptional profiles of Epstein-Barr virus-positive and negative primary CNS lymphomas

Alexandros Kourtesakis, Evgeniya Denisova, Octavian Henegariu, Joachim M. Baehring et al.
5 citations
Neuro-Oncology
CNS Lymphoma Diagnosis and Treatment
1.85
article

Distinct epigenetic and transcriptional profiles of Epstein-Barr virus-positive and negative primary CNS lymphomas

Alexandros Kourtesakis, Evgeniya Denisova, Octavian Henegariu, Joachim M. Baehring, Christel C. Herold‐Mende, Dirk C. Hoffmann, Leon D. Kaulen, Katharina Weidenauer, Felix Hinz, Jörg Dietrich, Benedikt Brors, Felix Sahm, Dennis Friedel, Wolfgang Wick, Ling Hai, Tobias Keßler, Sofia Doubrovinskaia, Georg T Scheffler, H. Rohdjeß
article en
5 citations

Abstract

EBV+ and EBV- PCNSL harbor distinct transcriptional and epigenetic profiles, corroborating them as distinctive biological subtypes. Uncovered differences provide novel insights into their pathobiology, may guide molecular diagnostics and targeted therapies.

Neuro-OncologyVol. 27(4)
Harvard University (US), German Cancer Research Center (DE), Heidelberg University (DE), University Hospital Heidelberg (DE), Yale University (US), Massachusetts General Hospital (US), Heidelberg University (US)
Deutsches Krebsforschungszentrum, Else Kröner-Fresenius-Stiftung
Responsible consumption and production
Openalex Percentile: Top 13%
CNS Lymphoma Diagnosis and Treatment
1.85
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