Distinct epigenetic and transcriptional profiles of Epstein-Barr virus-positive and negative primary CNS lymphomas
EBV+ and EBV- PCNSL harbor distinct transcriptional and epigenetic profiles, corroborating them as distinctive biological subtypes. Uncovered differences provide novel insights into their pathobiology, may guide molecular diagnostics and targeted therapies.
Authors
- Alexandros Kourtesakis (ORCID: https://orcid.org/0000-0002-7894-9131)
- Evgeniya Denisova (ORCID: https://orcid.org/0000-0001-6258-8055)
- Octavian Henegariu (ORCID: https://orcid.org/0000-0002-8971-1049)
- Joachim M. Baehring (ORCID: https://orcid.org/0000-0001-7755-6793)
- Christel C. Herold‐Mende (ORCID: https://orcid.org/0000-0002-1915-745X)
- Dirk C. Hoffmann (ORCID: https://orcid.org/0000-0003-1370-1933)
- Leon D. Kaulen (ORCID: https://orcid.org/0000-0002-5937-3376)
- Katharina Weidenauer
- Felix Hinz (ORCID: https://orcid.org/0009-0004-6394-1999)
- Jörg Dietrich (ORCID: https://orcid.org/0000-0001-8291-0136)
- Benedikt Brors (ORCID: https://orcid.org/0000-0001-5940-3101)
- Felix Sahm (ORCID: https://orcid.org/0000-0001-5441-1962)
- Dennis Friedel (ORCID: https://orcid.org/0009-0000-5067-3009)
- Wolfgang Wick (ORCID: https://orcid.org/0000-0002-6171-634X)
- Ling Hai (ORCID: https://orcid.org/0000-0001-8719-2727)
- Tobias Keßler (ORCID: https://orcid.org/0000-0001-8350-7074)
- Sofia Doubrovinskaia (ORCID: https://orcid.org/0009-0003-1727-8906)
- Georg T Scheffler
- H. Rohdjeß (ORCID: https://orcid.org/0009-0001-4985-1231)
Institutions
- Harvard University (US)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Yale University (US)
- Massachusetts General Hospital (US)
- Heidelberg University (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1093/neuonc/noae251
- Citations
- 5
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- Deutsches Krebsforschungszentrum
- Else Kröner-Fresenius-Stiftung