Ceftazidime-Cefazolin Empiric Therapy for Pediatric Gradenigo Syndrome

In the setting of delayed or absent culture results with suspicion of skull-base infection, our case supports the use of empiric antibiotic therapy with sufficient coverage of all common pathogens including <i>Streptococcus</i>/<i>Staphylococcus</i> and <i>Pseudomonas aeruginosa</i> species, the latter of which is often not adequately covered by antibiotic regimens described in the literature.