CD38 ligation in sepsis promotes nicotinamide phosphoribosyltransferase-mediated IL-6 production in kidney stromal cells
Our findings elucidate the implications of CD38 ligation in an LPS-induced sepsis model and uncover shared signalling pathways between mice and human sepsis. NAMPT signalling identified in this study may be a novel therapeutic target for mitigating systemic inflammation and kidney injury associated with severe sepsis.
Authors
- Hirofumi Watanabe (ORCID: https://orcid.org/0000-0003-2277-2784)
- Tadashi Otsuka (ORCID: https://orcid.org/0000-0002-0572-3764)
- Yoshikatsu Kaneko (ORCID: https://orcid.org/0000-0002-6396-0055)
- Shingo Maruyama (ORCID: https://orcid.org/0000-0002-6608-2219)
- Ichiei Narita (ORCID: https://orcid.org/0000-0001-7692-3096)
- Yasuhiro Kanda (ORCID: https://orcid.org/0000-0001-8131-8130)
- Yuya Suzuki (ORCID: https://orcid.org/0000-0003-1734-3838)
- Tomoya Katakai (ORCID: https://orcid.org/0000-0002-4290-7028)
- Riuko Ohashi (ORCID: https://orcid.org/0000-0001-5820-7870)
- Yusuke Takahashi (ORCID: https://orcid.org/0000-0001-8835-6295)
- Alexey Annenkov
Institutions
- Niigata University Medical and Dental Hospital (JP)
- Niigata University (JP)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1093/ndt/gfae269
- Citations
- 1
- Primary Topic
- Calcium signaling and nucleotide metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- Japan Society for the Promotion of Science