Disrupted balance between pro-inflammatory lipid mediators and anti-inflammatory specialized pro-resolving mediators is linked to hyperinflammation in patients with alcoholic hepatitis
AH patients exhibited significantly higher plasma levels of w-6 PLMs (PGD2 and LTB4) and SPM RvE1 compared to HDCs or HCs. Conversely, the SPM LXA4 was significantly downregulated in AH patients. Some of these altered LMs were found to correlate with AH disease severity and various inflammatory cytokines. Particularly, the LTB4/LXA4 ratio was substantially elevated in AH patients relative to HDCs and HCs. This altered ratio displayed a positive correlation with the MELD score. Importantly, the majority of dysregulated LMs, particularly PLMs, were normalized following alcohol abstinence.
Authors
- Vijay H. Shah (ORCID: https://orcid.org/0000-0001-7620-573X)
- Arun Jayant Sanyal (ORCID: https://orcid.org/0000-0001-8682-5748)
- Naga Chalasani (ORCID: https://orcid.org/0000-0003-4082-3178)
- Qigui Yu
- Wei Li (ORCID: https://orcid.org/0000-0003-4026-314X)
- Jing Yang (ORCID: https://orcid.org/0000-0003-1990-8345)
- Ying Xia (ORCID: https://orcid.org/0000-0002-8133-5413)
Institutions
- Virginia Commonwealth University (US)
- Mayo Clinic in Arizona (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.3389/fimmu.2024.1377236
- Citations
- 5
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Bill and Melinda Gates Foundation
- Virginia Commonwealth University
- National Institute on Alcohol Abuse and Alcoholism