Metagenomic characterization of the tracheobronchial microbiome in lung cancer
Lung lavages demonstrated oral microbiota enrichment in cases compared to controls, suggesting microaspiration and resultant inflammation. The oral commensals <i>Granulicatella adiacens</i> and <i>Neisseria subflava</i> were more abundant in the tracheobronchial lavages of lung cancer versus melanoma patients, implicating these microorganisms as potential lung cancer biomarkers, warranting further validation studies.
Authors
- Lary A. Robinson (ORCID: https://orcid.org/0000-0003-4579-0141)
- Shirlene Paul
- Alexis Bailey (ORCID: https://orcid.org/0000-0003-1541-1964)
- Stephanie Hogue (ORCID: https://orcid.org/0000-0002-5677-3518)
- Youngchul Kim (ORCID: https://orcid.org/0000-0002-2307-0330)
- Ram Thapa (ORCID: https://orcid.org/0000-0001-6128-4105)
- Christine M. Pierce (ORCID: https://orcid.org/0000-0002-0233-4894)
- N. Fuente
Institutions
- Moffitt Cancer Center (US)
Publication Details
- Journal
- Frontiers in Microbiomes
- Published
- 2024-11-21
- DOI
- https://doi.org/10.3389/frmbi.2024.1457537
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- H. Lee Moffitt Cancer Center and Research Institute
- Moffitt Cancer Center
- National Cancer Institute