Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study

This study elucidates the causal connections between specific interleukins, their receptors and ARDS, contributing significantly to the understanding of ARDS pathogenesis. These findings offer a foundation for further research and potential therapeutic interventions targeting these interleukins and receptors in ARDS management. The absence of reverse causation and pleiotropy, heterogeneity reinforces the robustness of these associations.

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Publication Details

Journal
Frontiers in Genetics
Published
2024-11-21
DOI
https://doi.org/10.3389/fgene.2024.1447661
Citations
1
Primary Topic
Asthma and respiratory diseases
Type
article
Field-Weighted Citation Impact
0.33

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article

Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study

Ji-chun Tang, Jiawei Ma, H. Fang
1 citations
Frontiers in Genetics
Asthma and respiratory diseases
0.33
article

Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study

Ji-chun Tang, Jiawei Ma, H. Fang
article en
1 citations

Abstract

This study elucidates the causal connections between specific interleukins, their receptors and ARDS, contributing significantly to the understanding of ARDS pathogenesis. These findings offer a foundation for further research and potential therapeutic interventions targeting these interleukins and receptors in ARDS management. The absence of reverse causation and pleiotropy, heterogeneity reinforces the robustness of these associations.

Frontiers in GeneticsVol. 15
Jiangnan University (CN), Wuxi Fourth People's Hospital (CN), Wuxi No.2 People's Hospital (CN)
Natural Science Foundation of Xinjiang
Good health and well-being
Openalex Percentile: Top 36%
Asthma and respiratory diseases
0.33
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Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study — Ji-chun Tang, Jiawei Ma, et al. · Frontiers in Genetics (2024) | TGRS Research Map | TGRS