Identification of key biomarkers related to fibrocartilage chondrocytes for osteoarthritis based on bulk, single-cell transcriptomic data
This study used a multi-omics approach to identify six FC-related OA biomarkers (BCL6, ABCA5, ABCA6, CITED2, NR1D1, and SLC7A8) and developed an exploratory risk model. Functional enrichment analysis revealed that the FoxO pathway may be linked to these markers, particularly implicating ABCA5 and ABCA6 in cholesterol homeostasis within chondrocytes. These findings highlight ABCA family members as novel contributors to OA pathogenesis and suggest new therapeutic targets.
Authors
- Bendan Lin
- Jinjin Ma (ORCID: https://orcid.org/0000-0002-5446-2214)
- Pingping Yao (ORCID: https://orcid.org/0000-0001-7551-3263)
- Xuanhao Lin
- Bailin Pan (ORCID: https://orcid.org/0000-0002-2563-8997)
- Chutong Lin (ORCID: https://orcid.org/0000-0002-0626-220X)
- Yufeng Zhang (ORCID: https://orcid.org/0000-0002-3154-7979)
- Laixi Zhou
- Chuangxin Lin
Institutions
- Sun Yat-sen University (CN)
- Shantou University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Shantou University Medical College (CN)
- Shantou Central Hospital (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.3389/fimmu.2024.1482361
- Citations
- 10
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.70
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Guangdong Province
- Special Fund Project for Science and Technology Innovation Strategy of Guangdong Province