Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progression
Overall, our IMO biobank captured the heterogeneous nature of IM, revealing mechanistic insights on IM pathogenesis and progression, offering an ideal platform for studying early gastric neoplastic transformation and chemoprevention.
Authors
- Sarah S K Yue (ORCID: https://orcid.org/0000-0003-4739-277X)
- Helen H.N. Yan (ORCID: https://orcid.org/0000-0001-5693-8231)
- Yin Tong (ORCID: https://orcid.org/0000-0001-6521-1915)
- Hoi Cheong Siu
- Yuanhua Huang (ORCID: https://orcid.org/0000-0003-3124-9186)
- Hans Clevers (ORCID: https://orcid.org/0000-0002-3077-5582)
- Ho Sang Hui
- Suet Yi Leung (ORCID: https://orcid.org/0000-0001-8614-4619)
- Shui Wa Yun
- April Chan (ORCID: https://orcid.org/0000-0002-4797-7009)
- Simon Law (ORCID: https://orcid.org/0000-0002-6518-5806)
- Matthew HSU (ORCID: https://orcid.org/0009-0006-2282-1725)
- Frank Pui-Ling Lai (ORCID: https://orcid.org/0000-0002-3801-8498)
- Joon‐Ho Choi (ORCID: https://orcid.org/0000-0002-0258-1369)
- Siu Lun Ho (ORCID: https://orcid.org/0000-0002-4716-5000)
- Wai Yin Tsui (ORCID: https://orcid.org/0009-0001-4900-3929)
- Siu Tsan Yuen (ORCID: https://orcid.org/0000-0002-1768-4184)
- Dessy Chan
- Annie S.Y. Chan
Institutions
- Royal Netherlands Academy of Arts and Sciences (NL)
- Queen Mary Hospital (CN)
- Hong Kong Science and Technology Parks Corporation (HK)
- Tung Wah Eastern Hospital (CN)
- St. Paul's Co-educational College (CN)
- Hong Kong Jockey Club (HK)
- Oncode Institute (NL)
- University of Hong Kong (HK)
Publication Details
- Journal
- Gut
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1136/gutjnl-2024-332594
- Citations
- 19
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 5.37
Funders
- Kadoorie Charitable Foundation