Late radiation-related lymphopenia after prostate stereotactic body radiation therapy plus or minus supplemental pelvic irradiation
The low incidence of high-grade lymphopenia within this elderly patient population further supports the safety of prostate SBRT plus or minus PNI for the treatment of prostate cancer. However, RRL was more severe when PNI was utilized. The effect of SBRT and PNI on lymphocytes in prostate cancer patients could act as a model for other cancers, specifically those involving treatment with immunomodulatory agents. Future studies should focus on the clinical implications of RRL and the effects of specifically irradiating lymphoid tissues on lymphocyte biology.
Authors
- Malika Danner
- Irfan Khan
- Z. Lee
- Simeng Suy
- Michael B. Atkins (ORCID: https://orcid.org/0000-0003-3901-9924)
- Peter R. Jermain (ORCID: https://orcid.org/0000-0002-3661-8254)
- Sean P. Collins (ORCID: https://orcid.org/0000-0002-2305-9836)
- Min Ji Koh (ORCID: https://orcid.org/0009-0004-1950-3860)
- Deepak Kumar (ORCID: https://orcid.org/0000-0001-6298-3565)
- Min Jung Koh (ORCID: https://orcid.org/0000-0001-9791-4463)
- Alan Zwart (ORCID: https://orcid.org/0000-0001-6834-9290)
- Kelly Gaudian
- Zoya Zwart
- Diya Kallam
- R Collins
Institutions
- North Carolina Central University (US)
- Georgetown University (US)
- George Washington University (US)
- Washington University in St. Louis (US)
- University of South Florida (US)
- Georgetown University Medical Center (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.3389/fonc.2024.1459732
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00