Modulation of the hepatic RANK-RANKL-OPG axis by combined C5 and CD14 inhibition in a long-term polytrauma model
Following experimental PT, dual inhibition of C5/CD14 resulted in altered, mainly reduced hepatic synthesis of proteins relevant to bone repair. However, a comprehensive investigation of the subsequent effects on the liver-bone axis are needed.
Authors
- İngo Marzi (ORCID: https://orcid.org/0000-0003-3677-2910)
- Frank Hildebrand (ORCID: https://orcid.org/0000-0001-7729-9838)
- Markus Huber‐Lang (ORCID: https://orcid.org/0000-0003-2359-6516)
- Tom Eirik Mollnes (ORCID: https://orcid.org/0000-0002-5785-802X)
- Martijn van Griensven (ORCID: https://orcid.org/0000-0001-5104-9881)
- Klemens Horst (ORCID: https://orcid.org/0000-0002-7162-6153)
- Ludmila Lupu (ORCID: https://orcid.org/0000-0002-0153-9345)
- Annette Palmer
- Anita Ignatius (ORCID: https://orcid.org/0000-0002-4782-1979)
- Rebecca Halbgebauer (ORCID: https://orcid.org/0000-0001-8060-2076)
- Johannes Greven (ORCID: https://orcid.org/0000-0003-2856-4804)
- Elizabeth R. Balmayor (ORCID: https://orcid.org/0000-0002-0484-4847)
- Ümit Mert (ORCID: https://orcid.org/0000-0001-6125-6040)
- Xing Zhang (ORCID: https://orcid.org/0000-0002-7569-8998)
- Yang Li (ORCID: https://orcid.org/0009-0000-4708-9530)
- Qun Zhao (ORCID: https://orcid.org/0000-0002-5039-9385)
- Lena Doerfer
Institutions
- Goethe University Frankfurt (DE)
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Universität Ulm (DE)
- Nordland Hospital (NO)
- University Hospital Frankfurt (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.3389/fimmu.2024.1434274
- Citations
- 3
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- Universität Ulm