Mediation effects of metabolites and sex hormones on the relationship between body mass index and breast cancer: Mendelian randomization analysis and mediation analysis
This study discovered that BMI increases ER<sup>+</sup>BC risk through the pathway of sex hormones (biologically available testosterone), and decreases BC risk through multiple metabolite pathways causally. These discoveries could offer insights into the development of preventive strategies and interventions for BC, while further investigations should delve into alternative feasible biological pathways.
Authors
- Wenwen Yang
- Min Chen (ORCID: https://orcid.org/0000-0002-1996-5422)
- Yanjiang Yang
Institutions
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.3389/fonc.2024.1449956
- Citations
- 1
- Primary Topic
- Cancer Risks and Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- University of Bristol
- Medical Research Council