Mendelian randomization and bioinformatics unveil potential links between gut microbial genera and colorectal cancer
This study establishes a potential relationship between five specific gut microbial genera, particularly <i>Defluviitaleaceae UCG011</i>, and CRC. Hub genes <i>PTPRD</i> and <i>DSCAM</i> provide insights into potential molecular mechanisms, suggesting the potential role of <i>Defluviitaleaceae UCG011</i> in modulating the initiation and progression of CRC. Further research is essential to validate these associations and delve deeper into therapeutic implications.
Authors
- Huan Wu (ORCID: https://orcid.org/0000-0002-7855-4543)
- Yun-Huan Zhen
- Fei Fei Huang (ORCID: https://orcid.org/0000-0003-0197-8687)
- Song Mu (ORCID: https://orcid.org/0009-0008-1929-0286)
- Bao-fang Zhang
- Haiyang Li (ORCID: https://orcid.org/0009-0002-2019-9419)
- Xiaoyun Li (ORCID: https://orcid.org/0000-0002-0102-2178)
- Long Wu (ORCID: https://orcid.org/0009-0007-5977-4747)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2024-11-21
- DOI
- https://doi.org/10.3389/fgene.2024.1379003
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Natural Science Foundation of China