A Biolayer Interferometry‐Based SARS‐COV‐2 Mpro‐Targeted Active Ingredients Recognition System: Construction and Application in Ligand Screening From Herbal Medicines
This study established a functional Mpro inhibitor screening system. Among the 10 components identified from G. fructus that bind to Mpro, DAAME and Gardoside displayed strong binding and inhibitory activity, indicating their potential as lead compounds for inhibiting SARS-CoV-2 viral replication.
Authors
- Mengqi Huo
- D. H. Zhang (ORCID: https://orcid.org/0000-0003-3010-5965)
- Jin‐Fa Tang
- Xianqing Ren (ORCID: https://orcid.org/0000-0002-8390-259X)
- Bing Han
- Yong‐Sheng Qiu (ORCID: https://orcid.org/0000-0003-1113-2597)
- Mingliang Zhang (ORCID: https://orcid.org/0000-0002-5363-1012)
- Xiaofei Chen (ORCID: https://orcid.org/0000-0002-5480-9724)
- Yao‐Dong Zhang
- Shuai Zhao (ORCID: https://orcid.org/0009-0004-2233-7453)
- Wei‐Xia Li
- Wei Wang (ORCID: https://orcid.org/0000-0001-8676-1190)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-6300-9334)
- Yuan Ren (ORCID: https://orcid.org/0000-0003-2842-6399)
Institutions
- Henan University of Traditional Chinese Medicine (CN)
- Zhengzhou University (CN)
- Zhengzhou Children's Hospital (CN)
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Phytochemical Analysis
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1002/pca.3462
- Citations
- 4
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.45