Identification, screening, and comprehensive evaluation of novel thrombin inhibitory peptides from the hirudo produced using pepsin
Overall, the results suggested that HHS provides new insights for searching and evaluating potential antithrombotic compounds. The obtained P1 can be structurally optimized for in-depth evaluation in animal and cellular experiments.
Authors
- Zirong Yi
- Dongying Qi
- Xueyan Li
- Guopeng Wang
- Fulu Pan
- Xinyu Wang
- Xiaoyu Chai
- Huan Liu (ORCID: https://orcid.org/0000-0002-5519-7336)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-4530-6754)
- Yiming Zhang (ORCID: https://orcid.org/0000-0003-1000-9108)
- Qianqian Wang (ORCID: https://orcid.org/0009-0003-4622-0199)
- Yanli Pan
- Yang Liu (ORCID: https://orcid.org/0000-0001-5586-623X)
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.3389/fphar.2024.1460053
- Citations
- 2
- Primary Topic
- Biochemical and Structural Characterization
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- China Academy of Chinese Medical Sciences