Clinical and pathological characteristics of immune checkpoint inhibitor-related fulminant myocarditis
The advent of immune checkpoint inhibitors (ICIs) has significantly improved cancer treatment. With the increasing use of ICIs, ICI-related myocarditis has been recognized. However, an evidence-based therapeutic strategy has not been established because of the limited knowledge on ICI-related myocarditis. Here, we present four cases of ICI-related fulminant myocarditis (FM). Three of the four cases resulted in fatal outcomes despite aggressive treatment with mechanical circulatory support and immunosuppressive therapy with corticosteroids. Given the poor prognosis of ICI-FM, the establishment of rapid and adequate therapeutic interventions on the basis of clinical and pathological evaluation is imperative.
Authors
- Takeshi Iwasaki (ORCID: https://orcid.org/0000-0001-5277-2932)
- Shouji Matsushima
- Kohtaro Abe (ORCID: https://orcid.org/0000-0003-4131-5423)
- Shintaro Kinugawa (ORCID: https://orcid.org/0000-0003-2559-0054)
- Kayo Misumi (ORCID: https://orcid.org/0000-0003-3441-1628)
- Shunsuke Katsuki (ORCID: https://orcid.org/0000-0001-7851-216X)
- Mikiko Hashisako (ORCID: https://orcid.org/0000-0001-5245-7342)
- Yuki Tateishi
- Keisuke Shinohara (ORCID: https://orcid.org/0000-0002-9489-3836)
- Hiroshi Kisanuki
- Takeo Fujino (ORCID: https://orcid.org/0000-0002-2886-3479)
- Yoshinao Oda (ORCID: https://orcid.org/0000-0001-9636-1182)
- Soshun Asakawa
- Kazuya Hosokawa (ORCID: https://orcid.org/0000-0002-5532-3961)
- Toru Hashimoto (ORCID: https://orcid.org/0000-0001-9607-0852)
- Shoei Yamamoto (ORCID: https://orcid.org/0009-0007-7740-6286)
- Taro Mori
- Kei Ikuta
- Ryo Izumi
- Wataru Otsuru
Institutions
- Kyushu University (JP)
- Kyushu University Hospital (JP)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1186/s40959-024-00288-0
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.41