Maternal infection of SARS-CoV-2 during the first and second trimesters leads to newborn telomere shortening
Maternal SARS-CoV-2 infection at the first and second trimesters leads to significantly shorter TL and earlier infection causes much more severe TL damage. The infection-mediated cell senescence and other histopathological abnormalities result in defective placental function through which fetal telomere homeostasis is impaired. Thus, vaccination against COVID-19 should be done in advance for women who plan pregnancy.
Authors
- Feng Kong (ORCID: https://orcid.org/0000-0002-6784-2638)
- Fengchun Gao (ORCID: https://orcid.org/0009-0004-5873-2535)
- Dawei Xu (ORCID: https://orcid.org/0000-0003-3141-4524)
- Yanhua Liu (ORCID: https://orcid.org/0000-0002-2737-8201)
- Lina Wang (ORCID: https://orcid.org/0000-0003-1457-0015)
- Junfeng Zhang (ORCID: https://orcid.org/0000-0001-5132-3975)
- Junmin Li (ORCID: https://orcid.org/0000-0003-0775-0878)
- Fangfei Liu (ORCID: https://orcid.org/0000-0003-0434-2828)
- Qixiang Shi
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Jinan Maternity And Care Hospital (CN)
- Second Hospital of Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
- Seventh People's Hospital of Dalian (CN)
- Shandong University of Finance and Economics (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1186/s12967-024-05879-0
- Citations
- 2
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- Cancerfonden
- Karolinska Institutet