Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration
Our data revealed that MGO-induced depression like-behavior and memory deficits resulted from disturbances in Trp, 5-HT, BDNF, and NGF levels, increased p-Tau and APP expression, neuroinflammation, and impaired redox status (Nrf-2/Ho-1/TXNRD1/Sirt3/5) in the brain.
Authors
- Sun Yeou Kim (ORCID: https://orcid.org/0000-0001-8044-5613)
- Myung Sook Oh (ORCID: https://orcid.org/0000-0001-8189-4066)
- Md. Samsuzzaman (ORCID: https://orcid.org/0009-0005-1707-6081)
- Hyun-Bum Kim (ORCID: https://orcid.org/0000-0003-1802-8952)
- Keun‐A Chang (ORCID: https://orcid.org/0000-0002-6157-6340)
- Hyeyoon Eo (ORCID: https://orcid.org/0000-0002-1532-613X)
- Jae Hyuk Lee (ORCID: https://orcid.org/0000-0002-4304-0198)
- Seong Min Hong (ORCID: https://orcid.org/0000-0002-7646-3138)
- Hyun‐Jun Park
- Myoung Gyu Park
Institutions
- University of Maryland, Baltimore (US)
- Gachon University (KR)
- Kyung Hee University (KR)
- Kyung Hee University East-West Neo Medical Center (KR)
Publication Details
- Journal
- Biological Research
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1186/s40659-024-00572-4
- Citations
- 21
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.30
Funders
- Gachon University
- Ministry of Education