Impact of cell geometry, cellular uptake region, and tumour morphology on 225Ac and 177Lu dose distributions in prostate cancer
Cell geometry simplifications may still allow robust results in simulation studies. Furthermore, the morphology of the tumour itself may make a larger impact on treatment response compared to other variables such as ratio of internalization. Finally, nucleus absorbed dose kernels were created that could enable microdosimetric studies with autoradiography.
Authors
- Julia Brosch-Lenz (ORCID: https://orcid.org/0000-0002-5680-5823)
- Arman Rahmim (ORCID: https://orcid.org/0000-0002-9980-2403)
- Cassandra Miller (ORCID: https://orcid.org/0000-0003-4594-442X)
- Ivan S. Klyuzhin (ORCID: https://orcid.org/0000-0003-0141-7628)
- Guillaume Chaussé (ORCID: https://orcid.org/0000-0002-4083-0805)
- Carlos Uribe (ORCID: https://orcid.org/0000-0003-3127-7478)
- Helena Koniar (ORCID: https://orcid.org/0000-0003-0794-9115)
- Kuangyu Shi (ORCID: https://orcid.org/0000-0002-8714-3084)
Institutions
- University of Bern (CH)
- BC Cancer Agency (CA)
- University of British Columbia (CA)
- University Hospital of Bern (CH)
- Spinal Cord Injury BC (CA)
- McGill University (CA)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1186/s40658-024-00700-9
- Citations
- 3
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Alliance de recherche numérique du Canada
- Natural Sciences and Engineering Research Council of Canada