Helicobacter pylori infection prevalence and inflammation severity in celiac disease: a retrospective analysis of 946 duodenal biopsies and serological tests

Introduction:The relationship between Helicobacter pylori (HP) and celiac disease (CD) has not been fully explained.We aimed to evaluate the prevalence of HP infection in CD and its relationship with the clinical course of the disease. Material and methods:The medical records of 946 patients over the age of 18 who underwent upper gastrointestinal system endoscopy in our tertiary health center between 2017 and 2019 were retrospectively reviewed.Biopsy results and requested serological tests for CD were evaluated.Results: The prevalence of HP in CD was found to be significantly lower when compared to the non-CD group.The rate of moderate and severe inflammation associated with HP was found to be significantly higher in CD than in the non-CD group.A significant difference was found between tissue transglutaminase (anti-tTG) antibody positivity rates based on the degree of HP inflammation.Conclusions: A negative relationship was found between HP prevalence and CD.