Myofibroblast-derived extracellular vesicles facilitate cancer stemness of hepatocellular carcinoma via transferring ITGA5 to tumor cells
Our findings elucidated a novel mechanism by which the EV-mediated transfer of ITGA5 from myofibroblasts to tumor cells augmented HCC stemness. ITGA5-targeting therapy helped prevent the progression of HCC and improved the efficacy of PD-L1 treatment.
Authors
- Jian Hong (ORCID: https://orcid.org/0000-0003-1084-3979)
- Keke Zhang (ORCID: https://orcid.org/0000-0002-5755-7059)
- Hongling Jia (ORCID: https://orcid.org/0000-0002-6383-9298)
- Chen Qu (ORCID: https://orcid.org/0000-0001-8889-4851)
- Mingrong Cao (ORCID: https://orcid.org/0000-0001-5672-2991)
- Lu He (ORCID: https://orcid.org/0000-0002-0391-0208)
- Zhiwei Chen (ORCID: https://orcid.org/0000-0002-5994-3922)
- Xiao Yang (ORCID: https://orcid.org/0009-0006-6826-8961)
- Jian Sun (ORCID: https://orcid.org/0009-0001-5467-3636)
- Ping Tao (ORCID: https://orcid.org/0000-0003-1518-3033)
- Jinyu Lv
- Liuyan Chen (ORCID: https://orcid.org/0000-0002-1804-1447)
Institutions
- Jinan University (CN)
- Sichuan Cancer Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1186/s12943-024-02170-0
- Citations
- 23
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 5.38